kamal
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Michael addition
Hi to all friends !
AGAIN !
I'm trying one reaction of making a Michael adduct by reacting an Acrylate based ketoester with l-alanine, but not having proper process references
for this.
Can I get some experimental/synthesis references for this reaction ?
Awaiting your nice suggetions !!
Regards,
Kamal
(mailbox@prolificint.com)
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Sriraman
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3-chloropropionitrile - Michael addition with sulfanamide is done bytaking excess of 3-chloropropionitrile with HCl gas purging at 55 deg C.
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kamal
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Sorry but I couldn't get your point.......
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Sriraman
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If you are looking for Michael addition across -CN to-C=NH
such michael additions are reported in some patents.
Sriraman
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Sriraman
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A procedure for Michael addition - Please refer US ptent 4731479
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