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Author: Subject: phenylacetonitrile synt from Pihkal
stimo-roll
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[*] posted on 15-12-2007 at 05:53
phenylacetonitrile synt from Pihkal


Hi. Interesting reaction for preparation phenylacetonitriles - http://www.erowid.org/library/books_online/pihkal/pihkal147.... Substituted bromobenzene reacted wia strong base (LDA) give yne-derevate, which reacts wia acetonitrile give subst-phenylacetonitrile. Anybody know this type reaction examples in literature? Can LDA be replaced with t-BuOK?

[Edited on 15-12-2007 by stimo-roll]

[Edited on 15-12-2007 by stimo-roll]
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stoichiometric_steve
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[*] posted on 15-12-2007 at 08:21


why bother, when it is clearly stated that it is not easy to purify the resulting mixture of products - and the yield is also shitty.
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vulture
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[*] posted on 15-12-2007 at 11:41


t-BuOK is not basic enough. And we don't like cookery threads here...



One shouldn't accept or resort to the mutilation of science to appease the mentally impaired.
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