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Author: Subject: Caprolactam reduction to azepane?
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[*] posted on 13-7-2023 at 08:35
Caprolactam reduction to azepane?

Hey everyone, few weeks ago i recently made some cyclohexanone oxime im planning to turn into caprolactam following the many procedures online.
Even if its a nice molecule in itself i was actually wondering if it would be possible to reduce it to azepane

Of course my first idea would be to use LAH (wich is have), however i am not rly aware about the reactivity of the cyclic amide in itself, if it would be reactive enough or even if it could open the cycle

I found a random wikipedia picture saying that NaBH4 and methane sulfonic acid could be used to but no references linked to it

I have access to most reagent that could be used to reduce it i believe so if anyone have ideas or acces to sites like scifinder i would gladly have a look at your propositions. My final goal would be to make a video on it cause i mean, lets be honest 7 member rings are cool

Anyway thanks for anyone who take the time to answer this post !
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[*] posted on 13-7-2023 at 18:23

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