Ketonitriles
A High-Yielding Preparation of -Ketonitriles
Yaohui Ji, William C. Trenkle,* and James V. Vowles
Org. Lett., 8 (6), 1161 -1163, 2006
Abstract:
Ketonitriles are important precursors for a wide variety of biologically active heterocycles. A facile procedure for the high-yielding acylation of
nitrile anions with unactivated esters to provide -ketonitriles is reported. The procedure is successful with enolizable and nonenolizable esters as
well as hindered nitrile anions.
Note:...."while decyanation provides ketones. (5.).....seems like they used 48% hydrobromic acid, reflux, to remove the CN
Ref: 5. Laufer, S. A.; Zimmermann, W.; Ruff, K. J. J. Med. Chem. 2004, 47, 6311-6325.
http://rapidshare.de/files/15642353/Stefan_A._Laufer__Werner...
[Edited on 16-3-2006 by solo]
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