Agari
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Triphenylphosphine Synthesis?
While doing reading on Carbon Tetrabromide,I came across a compund called Triphenylphosphine. After reading about Triphenylphosphine, I came across an
article that states that it could be used the Mitsunobu Reaction,the Appel Reaction, deoxygenation, and sulfonation. I am more interested in the first
2 reactions,so my question is: How can I synthesize triphenylphosphine?
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careysub
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You can buy 100 g of it on eBay for $28 including shipping.
[Edited on 24-10-2015 by careysub]
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Agari
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100 grams for 428$ is affordable yet does not appear to be a cost-effective trade-off. I created this thread asking for synthesis methods,please don't
tell me to buy it(Unless it's the only method of obtaining it).
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gdflp
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You can synthesize triphenylphosphine by the reaction of phosphorus trichloride with phenylmagnesium bromide. I believe there is a procedure
somewhere on this forum.
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Agari
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Quote: Originally posted by gdflp  | | You can synthesize triphenylphosphine by the reaction of phosphorus trichloride with phenylmagnesium bromide. I believe there is a procedure
somewhere on this forum. |
Can you please provide a link?
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careysub
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| Quote: Originally posted by Agari |
100 grams for 428$ is affordable yet does not appear to be a cost-effective trade-off. I created this thread asking for synthesis methods,please don't
tell me to buy it(Unless it's the only method of obtaining it). |
The wise words of Dan Vizine (I think) turn this around, don't make something unless you can't buy it (due to cost, lack of sources, of not wanting to
attract attention) - unless it is really the synthetic exercise you are after. If you just want it to employ in some other reactions, buying it is the
best idea.
Nobody cares if you buy triphenylphosphine (to the best of my knowledge) - it is cheap and readily available.
But it appears extremely costly and difficult to make in the home lab, requiring reagents like phosphorous trichloride AND phenylmagnesium AND sodium
metal. Sodium azide is also used in other methods.
A lot of chemicals are like this, easy and cheap in industrial scale processes all but impossible at home.
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Agari
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| Quote: Originally posted by careysub | | Quote: Originally posted by Agari |
100 grams for 428$ is affordable yet does not appear to be a cost-effective trade-off. I created this thread asking for synthesis methods,please don't
tell me to buy it(Unless it's the only method of obtaining it). |
The wise words of Dan Vizine (I think) turn this around, don't make something unless you can't buy it (due to cost, lack of sources, of not wanting to
attract attention) - unless it is really the synthetic exercise you are after. If you just want it to employ in some other reactions, buying it is the
best idea.
Nobody cares if you buy triphenylphosphine (to the best of my knowledge) - it is cheap and readily available.
But it appears extremely costly and difficult to make in the home lab, requiring reagents like phosphorous trichloride AND phenylmagnesium AND sodium
metal. Sodium azide is also used in other methods.
A lot of chemicals are like this, easy and cheap in industrial scale processes all but impossible at home. |
Oh lol,I thought that your price tag read 428$. I would like to synthesize it as a challenge,but if it can't be done,I may just simply buy it.
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UC235
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If you want to do it for funsies, buy the PPh3 and make a small amount of SbPh3. Antimony halides are much easier to make and handle (and obtain
starting materials for) than phosphorus halides. The product, unfortunately doesn't do Wittigs and similar reactions but can be quaternized and turned
into a ylide.
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Aqua-regia
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Grignard process (easy), you can translate with google: http://forum.lambdasyn.org/index.php/topic,2082.0.html
Indrustial pathway with molten sodium (need good practice):
http://v3.espacenet.com/origdoc?DB=EPODOC&IDX=CA1123460&...
[Edited on 25-10-2015 by Aqua-regia]
[Edited on 25-10-2015 by Aqua-regia]
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krishna
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Melt Sodium metal in xylene under vigorous stirring and add phosphorus trichloride. It forms
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