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Author: Subject: O-toluic acid synthesis is looking quite odd
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[*] posted on 13-3-2024 at 10:35


DRUG SYNTHESIS METHODS
AND MANUFACTURING TECHNOLOGY
OXIDATION OF SUBSTITUTED TOLUENES BY NITRIC ACID

P.V.Kazakov,1 S.V.Gorelenko
Pharmaceutical Chemistry Journal
Vol. 54, No. 1, April, 2020 (Russian Original Vol. 54, No. 1, January, 2020)
DOI 10.1007/s11094-020-02153-7


Abstract
Oxidation by HNO3 at atmospheric pressure of toluenes with electronegative substituents on the benzene ring was studied. A method enabling the corresponding benzoic acids to be obtained in high yields with minimal wastes was developed. The method could be used in the laboratory and in production of medicines.

Keywords: substituted toluenes, HNO3, halo- and nitrobenzoic acids.

Attachment: Oxidation of Substituted Toluenes by Nitric Acid.pdf (95kB)
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