4-Aminoantipyrine

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4-Aminoantipyrine
4-Aminoantipyrine original bottle and sample.jpg
Old ampyrone and original bottle
Names
IUPAC names
4-Amino-1,5-dimethyl-2-phenylpyrazol-3-one
4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
Other names
4-Aminoantipyrene
Aminoantipyrine
Aminoazophene
Ampyrone
Metapirazone
Metapyrazone
Solvapyrin A
Properties
C11H13N3O
Molar mass 203.245 g/mol
Appearance Yellow solid
Odor Odorless
Density 1.207 g/cm3
Melting point 105–110 °C (221–230 °F; 378–383 K)
Boiling point 309 °C (588 °F; 582 K) (decomposes)
5.6 g/100 ml
Vapor pressure ~0 mmHg
Hazards
Safety data sheet Sigma-Aldrich
Flash point 140.7 °C (285.3 °F; 413.8 K)
Lethal dose or concentration (LD, LC):
1,700 mg/kg (rat, oral)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

4-Aminoantipyrine or ampyrone is an organic compound with the chemical formula C11H13N3O, used as reagent in analytical chemistry. It is the main metabolite of the anti-inflammatory and antipyretic drug Aminopyrine.

Properties

Chemical

4-Aminoantipyrine will decompose when heated to high temperatures.

Physical

4-Aminoantipyrine is a yellow odorless solid, soluble in water. Old samples tend to be have a more dark yellow to orange hue, due to degradation.

Availability

Ampyrone is sold by chemical suppliers.

Preparation

4-Aminoantipyrine is cheaper to buy than synthesize.

Projects

  • Make various transition metal and lanthanide ligands
  • Colorimetric determination of phenols
  • Reagent for determination of glucose in the presence of phenol and peroxidase

Handling

Safety

4-Aminoantipyrine is irritant. It is the main metabolite of the analgesic, anti-inflammatory, and antipyretic drug Aminopyrine. Due to the risk of agranulocytosis its use as a drug is discouraged.[1]

Storage

In closed amber bottles, away from light.

Disposal

4-Aminoantipyrine should be strongly diluted before poured down the drain. Large amounts of this compound should be neutralized using an oxidizing mixture like Fenton's reagent, by adding it in small amounts. It can also be taken to waste disposal centers.

References

  1. https://en.wikipedia.org/wiki/Ampyrone

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