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Author: Subject: Catechol preparation
Chemi Pharma
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[*] posted on 12-3-2018 at 09:17

Reading this topic I remembered a study I've saw, telling about formylation of phenols with 80% yields.

They used anhydrous MgCl2, EtN3 and Paraformaldehyde in THF at reflux and this is described at orgsyn.

From the salicylaldehyde formed is easy to get cathecol by using H2O2 in basic media. This is also described at orgsyn.

The both synthesis is attached below:

Attachment: formylation of phenols - MgCl2 + Et3N + paraformaldehyde in THF.pdf (535kB)
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Attachment: CATECHOL from Salicylaldehyde or guayacol.pdf (168kB)
This file has been downloaded 10 times

[Edited on 13-3-2018 by Chemi Pharma]
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