Freshly prepared acetamide in a jar
| IUPAC name
| Systematic IUPAC name
|Molar mass||59.068 g/mol|
|Odor|| Odorless (pure)|
|Density||1.159 g/cm3 (20 °C)|
|Melting point||81.16 °C (178.09 °F; 354.31 K)|
|Boiling point||221.2 °C (430.2 °F; 494.3 K) (decomposes)|
|200 g/100 ml|
|Solubility|| Soluble in benzene, chloroform, ethanol, glycerol, isopropanol, methanol, pyridine|
Slightly soluble in diethyl ether, toluene
|Solubility in ethanol||50 g/100 ml|
|Solubility in pyridine||16.6 g/100 ml|
|Vapor pressure||0.0182 mmHg at 25 °C|
|Safety data sheet||Sigma-Aldrich|
|Flash point||126 °C (259 °F; 399 K)|
|Lethal dose or concentration (LD, LC):|
LD50 (Median dose)
|7,000 mg/kg (rat, oral)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Dehydration of acetamide in the presence of catalyst yields acetonitrile.
Acetamide is a colorless solid, very soluble in water.
It is sold by chemical suppliers.
Acetamide can be produced in the laboratory by dehydrating ammonium acetate.
Ammonolysis of ethyl acetate is also another route.
Alternatively acetamide can be obtained in excellent yield via ammonolysis of acetylacetone under conditions commonly used in reductive amination.
- Make acetonitrile
Acetamide doesn't appear to be very toxic.
Acetamide should be kept in closed glass or PE bottles.
Can be neutralized with a strong oxidizing mixture.