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Isopropanol bottle and sample.jpg
Isopropanol sample and its original bottle.
IUPAC name
Systematic IUPAC name
Other names
Dimethyl carbinol; IPA; iPrOH; Propan-2-ol; Rubbing alcohol; s-Propanol; sec-Propyl alcohol
Jmol-3D images Image
Molar mass 60.10 g/mol
Appearance Colorless volatile liquid
Odor Alcoholic, weak acetone-like
Density 0.786 g/cm3 (at 20 °C)
Melting point −89 °C (−128 °F; 184 K)
Boiling point 82.6 °C (180.7 °F; 355.8 K)
Solubility Miscible with methanol, ethanol, benzene
Insoluble in saline solution
Acidity (pKa) 16.5
Safety data sheet ScienceLab
Flash point Open cup: 11.7 °C (53.1 °F; 284.8 K)
Closed cup: 13 °C (55 °F)
Lethal dose or concentration (LD, LC):
12800 mg/kg (dermal, rabbit)
3600 mg/kg (oral, mouse)
5045 mg/kg (oral, rat)
6410 mg/kg (oral, rabbit)
53000 mg/m3 (inhalation, mouse)
12,000 ppm (rat, 8 hr)
Related compounds
Related compounds
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Isopropanol, or isopropyl alcohol, is a secondary alcohol. It provides the familiar smell of rubbing alcohol, where it is frequently used although this may be ethanol. Isopropanol is the largest carbon chain alcohol to be miscible with water and is a common OTC solvent.



Isopropanol is a generally nonreactive (inorganically speaking) alcohol. It can be dehydrated, and is a common reagent in organic chemistry.

Anhydrous isopropanol is used to neutralise small quantities of sodium or potassium metal, as the reaction with the alcohol is mild compared to with water and removes any reactive metal that may pose a danger if left in the lab. This property allows for the production of metal isopropoxides.

A violent runaway reaction happens when isopropanol comes into contact with a nitration bath. Toxic nitrogen dioxide is produced in a rapid reaction as the isopropanol is not nitrated but oxidised by the acids.

Isopropanol can be reacted with nitrous acid to for isopropyl nitrite and with mixed acids to form isopropyl nitrate.


Isopropanol is a clear, colorless liquid miscible in water. It's smell is described as closer to acetone than other short chain alcohols like ethanol. It burns on contact with cuts (like ethanol) and it's widely used as an antiseptic. It is a good, cheap solvent.


Isopropanol is available in concentrations anywhere from 60% to 99% (the rest being water and various stabilizers, additives) for a variety of applications, often cleaning electronics or sold as 'rubbing alcohol'. The most common concentrations are 70% and 91%. These store-bought solutions can be salted out up to a concentration of about 91% using sodium chloride, and nearly all water can be separated by salting out with sodium hydroxide, though this may inadvertently contaminate the isopropanol and produce sodium isopropoxide. Dry isopropanol has the potential to form explosive peroxides when distilled, so it is highly recommended that these distillations are carefully monitored if done at all.


Isopropanol is produced by hydrogenation of acetone over a nickel catalyst. It can also be obtained by hydrolysing esters containing an isopropyl group.




Isopropanol is flammable. It has low toxicity and it's much less toxic than methanol or ethylene glycol. Vapours of dry isopropanol can potentially be explosive.


Isopropanol should be stored in closed bottles, away from any oxidants and fire sources. As it is prone to forming peroxides over long periods of time, a small amount of antioxidant should be added, unless it already has. Most OTC isopropanol already has antioxidants in its composition.


Isopropanol can be safely burned. Old bottles that have been exposed to air should be checked for any peroxides and if there are any, they should be neutralized if safely possible.


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